Purpose: To determine the impact of stereotactic radiotherapy on the quality of life of patients with inoperable early-stage non-small-cell lung cancer (NSCLC). Overall survival, local tumor control, and toxicity were also evaluated in this prospective study. Methods and Materials: From January 2006 to February 2008, quality of life, overall survival, and local tumor control were assessed in 39 patients with pathologically confirmed T1 to 2N0M0 NSCLC. These patients were treated with stereotactic radiotherapy. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ) C30 and the QLQ LC13 lung cancer-specific questionnaire were used to investigate changes in quality of life. Assessments were done before treatment, at 3 weeks, and at 2, 4, 6, 9, and 12 months after treatment, until death or progressive disease. Toxicity was evaluated using common terminology criteria for adverse events version 3.0. Results: Emotional functioning improved significantly after treatment. Other function scores and QLQ C30 and QLQ LC13 lung symptoms (such as dyspnea and coughing) showed no significant changes. The overall 2-year survival rate was 62%. After a median follow-up of 17 months, 1 patient had a local recurrence (3%). No grade 4 or 5 treatment-related toxicity occurred. Grade 3 toxicity consisted of thoracic pain, which occurred in 1 patient within 4 months of treatment, while it occurred thereafter in 2 patients. Conclusions: Quality of life was maintained, and emotional functioning improved significantly after stereotactic radiotherapy for stage I NSCLC, while survival was acceptable, local tumor control was high, and toxicity was low.

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Keywords EORTC QLQ C30, EORTC QLQ LC13, Lung cancer, Quality of life, Stereotactic radiotherapy
Persistent URL dx.doi.org/10.1016/j.ijrobp.2009.04.080, hdl.handle.net/1765/27924
Citation
van der Voort van Zyp, N.C.M-G., Prévost, J.B., van der Holt, B., Braat, C., van Klaveren, R.J., Pattynama, P.M.T., … Nuyttens, J.J.M.E.. (2010). Quality of Life After Stereotactic Radiotherapy for Stage I Non-Small-Cell Lung Cancer. International Journal of Radiation: Oncology - Biology - Physics, 77(1), 31–37. doi:10.1016/j.ijrobp.2009.04.080