2010-02-01
Genome-wide association study of PR interval
Publication
Publication
Nature Genetics , Volume 42 - Issue 2 p. 153- 159
The electrocardiographic PR interval (or PQ interval) reflects atrial and atrioventricular nodal conduction, disturbances of which increase risk of atrial fibrillation. We report a meta-analysis of genome-wide association studies for PR interval from seven population-based European studies in the CHARGE Consortium: AGES, ARIC, CHS, FHS, KORA, Rotterdam Study, and SardiNIA (N = 28,517). We identified nine loci associated with PR interval at P 5 × 10 8. At the 3p22.2 locus, we observed two independent associations in voltage-gated sodium channel genes, SCN10A and SCN5A. Six of the loci were near cardiac developmental genes, including CAV1-CAV2, NKX2-5 (CSX1), SOX5, WNT11, MEIS1, and TBX5-TBX3, providing pathophysiologically interesting candidate genes. Five of the loci, SCN5A, SCN10A, NKX2-5, CAV1-CAV2, and SOX5, were also associated with atrial fibrillation (N = 5,741 cases, P 0.0056). This suggests a role for common variation in ion channel and developmental genes in atrial and atrioventricular conduction as well as in susceptibility to atrial fibrillation.
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| doi.org/10.1038/ng.517, hdl.handle.net/1765/28298 | |
| Nature Genetics | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Pfeufer, A., van Noord, C., Marciante, K., Arking, D., Larson, M., Smith, A. V., … Heckbert, S. (2010). Genome-wide association study of PR interval. Nature Genetics, 42(2), 153–159. doi:10.1038/ng.517 |
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