2010-10-01
Biodegradable xylitol-based elastomers: In vivo behavior and biocompatibility
Publication
Publication
Journal of Biomedical Materials Research. Part A , Volume 95 - Issue 1 p. 92- 104
Biodegradable elastomers based on polycondensation reactions of xylitol with sebacic acid, referred to as poly(xylitol sebacate) (PXS) elastomers have recently been developed. We describe the in vivo behavior of PXS elastomers. Four PXS elastomers were synthesized, characterized, and compared with poly(L-lactic-co-glycolic acid) (PLGA). PXS elastomers displayed a high level of structural integrity and form stability during degradation. The in vivo half-life ranged from approximately 3 to 52 weeks. PXS elastomers exhibited increased biocompatibility compared with PLGA implants.
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| doi.org/10.1002/jbm.a.32733, hdl.handle.net/1765/28602 | |
| Journal of Biomedical Materials Research. Part A | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Bruggeman, J., Bettinger, C., & Langer, R. (2010). Biodegradable xylitol-based elastomers: In vivo behavior and biocompatibility. Journal of Biomedical Materials Research. Part A, 95(1), 92–104. doi:10.1002/jbm.a.32733 |
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