BACKGROUND: Obesity is increasing rapidly among women all over the world. Obesity is a known risk factor for subfertility due to anovulation, but it is unknown whether obesity also affects spontaneous pregnancy chances in subfertile, ovulatory women. METHODS: We evaluated whether obesity affected the chance of a spontaneous pregnancy in a prospectively assembled cohort of 3029 consecutive subfertile couples. Women had to be ovulatory and had to have at least one patent tube, whereas men had to have a normal semen analysis. Time to spontaneous ongoing pregnancy within 12 months was the primary endpoint. RESULTS: The probability of a spontaneous pregnancy declined linearly with a body mass index (BMI) over 29 kg/m2. Corrected for possible related factors, women with a high BMI had a 4% lower pregnancy rate per kg/m2increase [hazard ratio: 0.96 (95% CI 0.91-0.99)]. CONCLUSIONS: These results indicate that obesity is associated with lower pregnancy rates in subfertile ovulatory women.

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Keywords Obesity, Pregnancy chance, Spontaneous conception, Subfertility
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van der Steeg, J.W., Steures, P., Eijkemans, M.J.C., Habbema, J.D.F., Hompes, P.G., Burggraaff, J.M., … Mol, B.W.J.. (2008). Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women. Human Reproduction, 23(2), 324–328. doi:10.1093/humrep/dem371