We describe a patient with a hepatotoxic reaction, presenting with general malaise, severe jaundice, and pruritus. This turned out to be caused by the, at first unrevealed, use of sildenafil. The injury seems to be hepatocanalicular, characterized by a hepatocellular liver test pattern, combined with extensive cholestasis on liver biopsy. One should bare in mind that the use of sildenafil may not be readily disclosed by the patient nor his doctor.

Additional Metadata
Keywords Drug toxicity, Hepatotoxicity, Sildenafil
Persistent URL dx.doi.org/10.1097/MEG.0b013e3282f2bbb5, hdl.handle.net/1765/29920
Citation
Wolfhagen, F.H.J, Vermeulen, H, de Man, R.A, & Lesterhuis, W. (2008). Initially obscure hepatotoxicity attributed to sildenafil. European Journal of Gastroenterology and Hepatology, 20(7), 710–712. doi:10.1097/MEG.0b013e3282f2bbb5