Conserved pattern of antisense overlapping transcription in the homologous ERCC-1 and yeast RAD10 DNA repair gene regions.
We report that the genes for the homologous Saccharomyces cerevisiae RAD10 and human ERCC-1 DNA excision repair proteins harbor overlapping antisense transcription units in their 3' regions. Since naturally occurring antisense transcription is rare in S. cerevisiae and humans (this is the first example in human cells), our findings indicate that antisense transcription in the ERCC-1-RAD10 gene regions represents an evolutionarily conserved feature.
|Keywords||*DNA Repair, *Genes, *Genes, Overlapping, *Transcription, Genetic, 0 (DNA, Fungal), 0 (RNA, Antisense), 63231-63-0 (rna), 9007-49-2 (dna), Base Sequence, Comparative Study, DNA, Fungal/genetics, DNA/genetics, Evolution, Genes, Fungal, Human, Molecular Sequence Data, RNA, Antisense, RNA/*genetics, Restriction Mapping, Saccharomyces cerevisiae/genetics, Support, Non-U.S. Gov't, Support, U.S. Gov't, Non-P.H.S., Support, U.S. Gov't, P.H.S.|
van Duin, M., van den Tol, J., Hoeijmakers, J.H.J., Bootsma, D., Rupp, I.P., Reynolds, P., … Prakash, S.. (1989). Conserved pattern of antisense overlapping transcription in the homologous ERCC-1 and yeast RAD10 DNA repair gene regions.. Molecular and Cellular Biology, 9, 1794–1798. Retrieved from http://hdl.handle.net/1765/3005