Population imaging of ongoing neuronal activity in the visual cortex of awake rats
It is unclear how the complex spatiotemporal organization of ongoing cortical neuronal activity recorded in anesthetized animals relates to the awake animal. We therefore used two-photon population calcium imaging in awake and subsequently anesthetized rats to follow action potential firing in populations of neurons across brain states, and examined how single neurons contributed to population activity. Firing rates and spike bursting in awake rats were higher, and pair-wise correlations were lower, compared with anesthetized rats. Anesthesia modulated population-wide synchronization and the relationship between firing rate and correlation. Overall, brain activity during wakefulness cannot be inferred using anesthesia.
|Persistent URL||dx.doi.org/10.1038/nn.2140, hdl.handle.net/1765/30169|
Greenberg, D.S, Houweling, A.R, & Kerr, J.N.D. (2008). Population imaging of ongoing neuronal activity in the visual cortex of awake rats. Nature Neuroscience, 11(7), 749–751. doi:10.1038/nn.2140