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C. Troelstra (Christine), R.M. Landsvater, J. Wiegant, M. van der Ploeg, G. Viel, C.H.C.M. Buys and J.H.J. Hoeijmakers (Jan)

1992

Localization of the nucleotide excision repair gene ERCC-6 to human chromosome 10q11-q21.

Publication

Publication

Genomics , Volume 12 p. 745- 749

We have cloned the human DNA excision repair gene ERCC6 by virtue of its ability to correct the uv sensitivity of Chinese hamster overy cell mutant UV61. This mutant is a member of complementation group 6 of the nucleotide excision repair-deficient rodent mutants. By means of in situ hybridization and Southern blot analysis of mouse x human somatic cell hybrids, the gene was localized to human chromosome 10q11-q21. An RFLP detected within the ERCC6 locus can be helpful in linkage analysis.

Additional Metadata
Keywords *Chromosomes, Human, Pair 10, Animals, CHO Cells, Chromosome Mapping, DNA Repair/*genetics/radiation effects, Female, Hamsters, Human, Hybrid Cells, Linkage (Genetics), Male, Mutation, Pedigree, Polymorphism, Restriction Fragment Length, Restriction Mapping, Support, Non-U.S. Gov't, Ultraviolet Rays
Persistent URL hdl.handle.net/1765/3037
Journal Genomics
Organisation Erasmus MC: University Medical Center Rotterdam
Citation
Troelstra, C., Landsvater, R. M., Wiegant, J., van der Ploeg, M., Viel, G., Buys, C. H. C. M., & Hoeijmakers, J. (1992). Localization of the nucleotide excision repair gene ERCC-6 to human chromosome 10q11-q21. Genomics, 12, 745–749. Retrieved from http://hdl.handle.net/1765/3037
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