We have cloned the human DNA excision repair gene ERCC6 by virtue of its ability to correct the uv sensitivity of Chinese hamster overy cell mutant UV61. This mutant is a member of complementation group 6 of the nucleotide excision repair-deficient rodent mutants. By means of in situ hybridization and Southern blot analysis of mouse x human somatic cell hybrids, the gene was localized to human chromosome 10q11-q21. An RFLP detected within the ERCC6 locus can be helpful in linkage analysis.

, , , , , , , , , , , , , , , ,
hdl.handle.net/1765/3037
Genomics
Erasmus MC: University Medical Center Rotterdam

Troelstra, C., Landsvater, R. M., Wiegant, J., van der Ploeg, M., Viel, G., Buys, C. H. C. M., & Hoeijmakers, J. (1992). Localization of the nucleotide excision repair gene ERCC-6 to human chromosome 10q11-q21. Genomics, 12, 745–749. Retrieved from http://hdl.handle.net/1765/3037