The Role of SOCS3 Signaling in Ulcerative Colitis and Ulcerative Colitis-related Carcinogenesis
Cytokine-signaling plays an important role in IBD. Proinflammatory cytokines like IL-6 contribute to the protection against pathogens, whereas they are also involved in chronic inflammation and are able to drive the survival and proliferation of cancer cells. Anti-inflammatory cytokines like IL-10 could help-out with the resolution of inflammation or prevent autoimmunity. On the other hand these anti-inflammatory cytokines can contribute to cancer development by inhibiting proper immune surveillance. All these effect warrant proper regulation of cytokine-signaling especially in a complex environment like the intestinal mucosa. In this thesis we focus on the role of SOCS3 the inhibitor of STAT3-signaling and its role in UC and UC-related CRC.
|Publisher||Erasmus MC: University Medical Center Rotterdam|
|Promotor||Kuipers, E.J. (Ernst)|
|Sponsor||Financial support for printing this thesis was kindly given by: Dr. Falk Pharma Benelux B.V., Abbott B.V., Ferring B.V., UCB Pharma B.V., MSD Nederland B.V., Greiner bio-one, Pentax Nederland B.V., Dynavin GmbH, the Nederlandse Vereniging voor Gastroenterologie and the Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam|
|Keywords||UC-CRC, IL-6, SOCS3, STAT3, UC|
Li, Y.. (2012, January 11). The Role of SOCS3 Signaling in Ulcerative Colitis and Ulcerative Colitis-related Carcinogenesis . Erasmus MC: University Medical Center Rotterdam. Retrieved from http://hdl.handle.net/1765/30808