A multiplex SNP assay for the dissection of human Y-chromosome haplogroup O representing the major paternal lineage in East and Southeast Asia
The majority of human Y chromosomes in men from East and Southeast Asia, and a considerable proportion of Oceanian men, especially those from Remote Oceania, belong to haplogroup O, characterized by a 5-bp deletion known as M175 (rs2032678). Recent advances in Y-SNP (single-nucleotide polymorphism) discovery have substantially improved the phylogenetic resolution of haplogroup O sublineages. By taking advantage of this recent knowledge, we hereby introduce a sensitive Y-SNP multiplex genotyping assay for the dissection of haplogroup O into its most significant sublineages. The multiplex assay thus provides an efficient way to infer patrilineal biogeographic ancestry in males of Asian/Oceanian patrilineal descent, and is suitable for applications in human population genetics, anthropological, genealogical, as well as forensic studies.
|Keywords||East Asia, SNP multiplex, Southeast Asia, Y chromosome, haplogroup O-M175, patrilineal ancestry, phylogeny, subhaplogroups|
|Persistent URL||dx.doi.org/10.1038/jhg.2011.120, hdl.handle.net/1765/31595|
van Oven, M., van den Tempel, N., & Kayser, M.H.. (2012). A multiplex SNP assay for the dissection of human Y-chromosome haplogroup O representing the major paternal lineage in East and Southeast Asia. Journal of Human Genetics, 57(1), 65–69. doi:10.1038/jhg.2011.120