Background: Although peri-strut low-intensity area (PLIA) is frequently observed on post-stenting optical coherence tomography (OCT) images, the histology associated with PLIA is undocumented. Methods and Results: The 36 porcine coronary lesions treated with bare-metal (BMS: n=16) or drug-eluting (DES: n=20) stents were assessed by OCT and histology at 28 days. DES showed a significantly higher incidence of PLIA than BMS. Also, +PLIA stents had greater neointima than -PLIA stents. Histological analysis revealed the existence of fibrinoid and proteoglycans at the site of PLIA. Conclusions: PLIA might be represented by the presence of fibrinoid and proteoglycans, and associated with neointimal proliferation after stenting.

Additional Metadata
Keywords Drug-eluting stent (DES), Optical coherence tomography (OCT), Restenosis
Persistent URL dx.doi.org/10.1253/circj.CJ-10-0189, hdl.handle.net/1765/33013
Citation
Teramoto, T, Ikeno, F, Otake, H, Lyons, J.K, van Beusekom, H.M.M, Fearon, W.F, & Yeung, A.C. (2010). Intriguing peri-strut low-intensity area detected by optical coherence tomography after coronary stent deployment. Japanese Circulation Journal, 74(6), 1257–1259. doi:10.1253/circj.CJ-10-0189