The 2009 H1N1 influenza pandemic provided an opportunity to study human virus-specific T cell responses after infection with a novel influenza virus against which limited humoral immunity existed in the population. Here we describe the magnitude, kinetics, and nature of the virus-specific T cell response using intracellular gamma interferon (IFN-γ) staining and fluorochrome-labeled major histocompatibility complex (MHC) class I-peptide complexes. We demonstrate that influenza virus-infected patients develop recall T cell responses that peak within 1 week postinfection and that contract rapidly. In particular, effector cell frequencies declined rapidly postinfection in favor of relatively larger proportions of central memory cells.

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Journal Journal of Virology
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Hillaire, M.L.B, Trierum, S.E, Bodewes, R, van Baalen, C.A, van Binnendijk, R.S, Koopmans, M, … Rimmelzwaan, G.F. (2011). Characterization of the human CD8 + T cell response following infection with 2009 pandemic influenza H1N1 virus. Journal of Virology, 85(22), 12057–12061. doi:10.1128/JVI.05204-11