Objective: We sought to examine the associations of maternal C-reactive protein (CRP) levels with fetal growth and the risks of neonatal complications. Study Design: CRP levels were measured in early pregnancy in 6016 women. Main outcome measures were fetal growth in each trimester and neonatal complications. Results: As compared to the reference group (CRP levels <5 mg/L), elevated maternal CRP levels (<25 mg/L) were associated with lower estimated fetal weight in third trimester and lower weight at birth (differences: -29 g, 95% confidence interval [CI], -58 to 0 and -128 g, 95% CI, -195 to -60, respectively). Elevated maternal CRP levels were also associated with an increased risk of a small size for gestational age in the offspring (adjusted odds ratio, 2.94; 95% CI, 1.615.36). Conclusion: Maternal CRP levels in early pregnancy are associated with fetal growth restriction and increased risks of neonatal complications.

Additional Metadata
Keywords C-reactive protein, cohort studies, fetal growth, inflammation, neonatal complications, pregnancy
Persistent URL dx.doi.org/10.1016/j.ajog.2011.03.049, hdl.handle.net/1765/33345
Citation
Ernst, G.D.S., de Jonge, L.L., Hofman, A., Lindemans, J., Russcher, H., Steegers-Theunissen, R.P.M., & Jaddoe, V.W.V-K.. (2011). C-reactive protein levels in early pregnancy, fetal growth patterns, and the risk for neonatal complications: The Generation R Study. American Journal of Obstetrics & Gynecology, 205(2). doi:10.1016/j.ajog.2011.03.049