Objectives: The objective was to evaluate the impact of gender on long-term survival of patients who underwent non-cardiac vascular surgery. Design, Material and Methods: Our prospectively collected data contained information on 560 patients undergoing carotid endarterectomy (CEA), 923 elective abdominal aortic aneurysm repairs (AAA) and 1046 lower limb reconstructions (LLR). Patient characteristics and long-term mortality of women were compared to that of men. Kaplan-Meier (KM) survival curves were constructed for men and women, on which we superimposed age- and sex-matched KM survival curves of the general population. Cox proportional hazards regression was used to identify risk factors for mortality. Results: Men in the CEA group had statistically significant higher all-cause mortality, hazard rate ratio (HRR) 1.41 (95% CI 1.01-1.98) No differences in mortality between the genders were observed in the AAA and LLR groups. Overall, men had more co-morbidities but received more disease-specific medication compared to women. Women retained their higher life expectancy after CEA but lost it in the AAA and LLR groups. Conclusion: Women retain their higher life expectancy after CEA; however, after AAA repair and LLR, this advantage is lost. Both men and women received too little disease-specific medication, but women were worse off.

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Keywords Abdominal aortic aneurysm repair, Carotid endarterectomy, Gender, Long-term follow-up, Lower leg revascularisation, Survival
Persistent URL dx.doi.org/10.1016/j.ejvs.2011.06.029, hdl.handle.net/1765/34157
Grootenboer, N, Hunink, M.G.M, Hoeks, S.E, Hendriks, J.M, van Sambeek, M.R.H.M, & Poldermans, D. (2011). The impact of gender on prognosis after non-cardiac vascular surgery. European Journal of Vascular and Endovascular Surgery, 42(4), 510–516. doi:10.1016/j.ejvs.2011.06.029