Increased signaling of the pro-inflammatory cytokine tumor necrosis factor-α (TNF-α) elicits apoptosis of skeletal muscle cells in various animal models. Within a population-based prospective follow up study of elderly people aged 85 years we show that a high innate production capacity of TNF-α precedes a steeper decline in muscle strength over time.

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Keywords Cytokine production capacity, Elderly people, Handgrip strength, Human, Inflammation, Muscle weakness, TNF-α
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Taekema, D.G., Westendorp, R.G.J., Frölich, M., & Gussekloo, J.. (2007). High innate production capacity of tumor necrosis factor-α and decline of handgrip strength in old age. Mechanisms of Ageing and Development, 128(9), 517–521. doi:10.1016/j.mad.2007.07.001