High innate production capacity of tumor necrosis factor-α and decline of handgrip strength in old age
Increased signaling of the pro-inflammatory cytokine tumor necrosis factor-α (TNF-α) elicits apoptosis of skeletal muscle cells in various animal models. Within a population-based prospective follow up study of elderly people aged 85 years we show that a high innate production capacity of TNF-α precedes a steeper decline in muscle strength over time.
|Keywords||Cytokine production capacity, Elderly people, Handgrip strength, Human, Inflammation, Muscle weakness, TNF-α|
|Persistent URL||dx.doi.org/10.1016/j.mad.2007.07.001, hdl.handle.net/1765/35214|
|Journal||Mechanisms of Ageing and Development|
Taekema, D.G, Westendorp, R.G.J, Frölich, M, & Gussekloo, J. (2007). High innate production capacity of tumor necrosis factor-α and decline of handgrip strength in old age. Mechanisms of Ageing and Development, 128(9), 517–521. doi:10.1016/j.mad.2007.07.001