Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/ myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERK- signaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role in the pathogenesis of JMML.

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Keywords BRAF, Juvenile myelomonocytic leukemia
Persistent URL dx.doi.org/10.3324/haematol.11493, hdl.handle.net/1765/36012
Citation
de Vries, A.C, Stam, R.W, Kratz, C.P, Zenker, M, Niemeyer, C.M, & van den Heuvel-Eibrink, M.M. (2007). Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia. Haematologica, 92(11), 1574–1575. doi:10.3324/haematol.11493