The Efficacy of Drugs for the Treatment of LUTS/BPH, A Study in 6 European Countries
Objectives: This paper profiles the usage and effectiveness of various LUTS/BPH drugs in real-life practice. Method: The TRIUMPH study recorded the treatment and outcomes of 2351 newly-presenting LUTS/BPH patients in 6 European countries over a 1-year follow-up period. At each visit the clinician recorded the treatment, co-morbidities, complications and drugs prescribed, and the patient completed an IPSS questionnaire. The results were analysed using change in IPSS as the primary outcome measure. RESULTS: Over the study period 74.9% of patients were prescribed medication, the majority (83% of those medicated) were prescribed only a single drug. Tamsulosin was the most commonly prescribed drug in all countries (38% of medicated cases), although with national variation from 24% in Poland to 70% in Italy. The alpha-blockers were the most effective, with a mean reduction of 6.3 IPSS points. Finasteride was slightly less effective (4.1 points). Significant improvements were seen in 43% of patients on phytotherapy with Serenoa repens or Pygeum africanum compared to 57% of those on finasteride and 68% on alpha-blockers. The only combination therapy found to produce a statistically significant improvement over the use of individual drugs was finasteride + tamsulosin (8.1 points compared to 6.7 for tamsulosin alone and 4.2 for finasteride alone). Conclusions: All drug treatments showed some improvement over watchful-waiting for most patients over the study period: the alpha-blockers were found to be the most effective. There were marked national differences in prescribing patterns, both in individual drug choice and in the use of combination therapies.
|Keywords||Alpha-blockers, Benign prostatic hyperplasia, Finasteride, International prostate symptom score, Lower urinary tract symptoms, Phytotherapy, TRIUMPH|
|Persistent URL||dx.doi.org/10.1016/j.eururo.2006.06.012, hdl.handle.net/1765/36153|
Hutchison, A., Farmer, R., Verhamme, K.M.C., Berges, R., & Navarrete, R.V.. (2007). The Efficacy of Drugs for the Treatment of LUTS/BPH, A Study in 6 European Countries. European Urology, 51(1), 207–216. doi:10.1016/j.eururo.2006.06.012