Validation of an ELISA for the diagnosis of recent Campylobacter infections in Guillain-Barré and reactive arthritis patients
Weeks or months following Campylobacter infection, a small proportion of infected individuals develop Guillain-Barrésyndrome (GBS) or reactive arthritis (ReA). Stool culture for Campylobacter is often negative in these patients, and serology is therefore the method of choice for diagnosing a recent infection with Campylobacter. This study developed a capture ELISA system to detect anti- Campylobacter IgA and IgM antibodies indicative of a recent infection. The sensitivity of the assay was 82.0% in uncomplicated Campylobacter enteritis patients, 96.2% in GBS patients who were culture-positive for Campylobacter, and 93.1% in culture-positive ReA patients, with a specificity of 93.0%. The assay allows identification of Campylobacter infection in patients with post-infectious neurological and rheumatological complications.
|Keywords||Arthritis, Campylobacter infections, Diagnosis, ELISA, Guillain-Barré syndrome, Joint pain|
|Persistent URL||dx.doi.org/10.1111/j.1469-0691.2007.01765.x, hdl.handle.net/1765/36732|
|Journal||Clinical Microbiology and Infection|
Ang, C.W, Krogfelt, K.A, Herbrink, P, Keijser, J, van Pelt, W, Dalby, T, … Visser, C.E. (2007). Validation of an ELISA for the diagnosis of recent Campylobacter infections in Guillain-Barré and reactive arthritis patients. Clinical Microbiology and Infection, 13(9), 915–922. doi:10.1111/j.1469-0691.2007.01765.x