In this paper we describe a combination of the mass spectrometric techniques MALDI-TOF/TOF and MALDI-FTMS to identify proteins in complex samples using prespotted MALDI target plates. By this procedure accurate FTMS mass measurements and TOF/TOF data are obtained from the same spot. We have found that this combination of techniques leads to more reliable identification of peptides.

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Keywords FTMS, MALDI-TOF/TOF, Peptide identification, Proteomics
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Dekker, L.J.M., Burgers, P.C., Güzel, C., & Luider, T.M.. (2007). FTMS and TOF/TOF mass spectrometry in concert: Identifying peptides with high reliability using matrix prespotted MALDI target plates. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 847(1), 62–64. doi:10.1016/j.jchromb.2006.08.031