BACKGROUND AND DESIGN: The effect of the cholesteryl ester transfer protein (CETP) I405V polymorphism on lipid levels, atherosclerosis and myocardial infarction (MI) was examined in 6421 participants from the Rotterdam Study. METHODS: Quantitative outcomes were studied with linear models; Cox models were used to assess MI risk. RESULTS: High-density lipoprotein cholesterol (HDL) increased by 0.06 [95% confidence interval (CI): 0.03, 0.09] mmol/l in VV carriers. The V allele was further associated with decreased MI risk in men [hazard ratio (95% confidence interval)=0.57 (0.45, 0.73), VV versus II] (Ptrend=0.02). CONCLUSION: This study provides additional evidence for the association of CETP with HDL levels and suggests that CETP is an atherogenic protein increasing the risk of MI.

Additional Metadata
Keywords Cholesteryl ester transfer protein, High-density lipoprotein, Myocardial infarction
Persistent URL dx.doi.org/10.1097/HJR.0b013e32801101aa, hdl.handle.net/1765/37117
Citation
Isaacs, A.J, Sayed-Tabatabaei, F.A, Hofman, A, Oostra, B.A, Klungel, O.H, Maitland-vander Zee, A.-H, … Tikka-Kleemola, P. (2007). The cholesteryl ester transfer protein I405V polymorphism is associated with increased high-density lipoprotein levels and decreased risk of myocardial infarction: The Rotterdam Study. European Journal of Cardiovascular Prevention & Rehabilitation, 14(3), 419–421. doi:10.1097/HJR.0b013e32801101aa