BACKGROUND AND DESIGN: The effect of the cholesteryl ester transfer protein (CETP) I405V polymorphism on lipid levels, atherosclerosis and myocardial infarction (MI) was examined in 6421 participants from the Rotterdam Study. METHODS: Quantitative outcomes were studied with linear models; Cox models were used to assess MI risk. RESULTS: High-density lipoprotein cholesterol (HDL) increased by 0.06 [95% confidence interval (CI): 0.03, 0.09] mmol/l in VV carriers. The V allele was further associated with decreased MI risk in men [hazard ratio (95% confidence interval)=0.57 (0.45, 0.73), VV versus II] (Ptrend=0.02). CONCLUSION: This study provides additional evidence for the association of CETP with HDL levels and suggests that CETP is an atherogenic protein increasing the risk of MI.

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Keywords Cholesteryl ester transfer protein, High-density lipoprotein, Myocardial infarction
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Isaacs, A.J, Sayed-Tabatabaei, F.A, Hofman, A, Oostra, B.A, Klungel, O.H, Maitland-vander Zee, A.-H, … Tikka-Kleemola, P. (2007). The cholesteryl ester transfer protein I405V polymorphism is associated with increased high-density lipoprotein levels and decreased risk of myocardial infarction: The Rotterdam Study. European Journal of Cardiovascular Prevention & Rehabilitation, 14(3), 419–421. doi:10.1097/HJR.0b013e32801101aa