2004-11-10
Osteoporosis from genes to phenotypes
Publication
Publication
Ostoporose van genen tot fenotypen
Osteoporosis is a leading public health problem in our rapidly growing, aging population. It is a systemic skeletal disease characterized by reduced bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. Family and twin studies have shown that osteoporosis and its associated phenotypes are under strong genetic control. In addition, it has been shown than not one major locus is responsible of the susceptibility to develop osteoporosis; instead, diverse genetic and environmental factors involved with the disease have confi rmed its complex multifactorial nature.
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| The Departments of Internal Medicine and Epidemiology & Biostatistics of the Erasmus Medical Center, GE Healthcare Lunar Corporation, and the Dutch Society for Calcium and Bone Metabolism (NVCB) provided fi nancial support for the publication of this thesis | |
| C.M. van Duijn (Cornelia) , H.A.P. Pols (Huib) | |
| Erasmus University Rotterdam | |
| hdl.handle.net/1765/37412 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Rivadeneira Ramirez, F. (2004, November 10). Osteoporosis from genes to phenotypes. Retrieved from http://hdl.handle.net/1765/37412 |
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