ADDIS: A decision support system for evidence-based medicine
Clinical trials are the main source of information for the efficacy and safety evaluation of medical treatments. Although they are of pivotal importance in evidence-based medicine, there is a lack of usable information systems providing data-analysis and decision support capabilities for aggregate clinical trial results. This is partly caused by unavailability (i) of trial data in a structured format suitable for re-analysis, and (ii) of a complete data model for aggregate level results. In this paper, we develop a unifying data model that enables the development of evidence-based decision support in the absence of a complete data model. We describe the supported decision processes and show how these are implemented in the open source ADDIS software. ADDIS enables semi-automated construction of meta-analyses, network meta-analyses and benefit-risk decision models, and provides visualization of all results.
|Keywords||clinical trial, data model, decision analysis, evidence synthesis, evidence-based medicine|
|Persistent URL||dx.doi.org/10.1016/j.dss.2012.10.005, hdl.handle.net/1765/37495|
van Valkenhoef, G., Tervonen, T., Zwinkels, T., de Brock, B., & Hillege, H.L.. (2012). ADDIS: A decision support system for evidence-based medicine . Decision Support Systems, 1–29. doi:10.1016/j.dss.2012.10.005