Isolation of a somatomedin binding protein from human preterm amniotic fluid : development of a radioimmunoassay
This thesis study was undertaken in order to investigate the nature and biological behavior of a somatornedin binding protein, identified in preterrn amniotic fluid (AF). Somatomedin (SM) is the generic designation applied to a family of serum peptide growth factors which are growth hormone dependent, stimulate incorporation of sulphate into cartilage, have insulin-like actions on nonskeletal tissues and increase mitosis in a wide variety of cultured cells. Thusfar two peptides have been fully characterized: insulin-like growth factor I (IGF-I), shown to be identical to sornatomedin-C, and insulin-like growth factor II (IGF-II). IGF-I and IGF-II have a 62% aminoacid sequence identity and are 38-48% homologous with the A and B domains of human pro-insulin.
|Keywords||amiotic fluid, endocrinology, isolation, placenta, protein, somatomedin|
|Promotor||Visser, H.K.A. (Henk) , Guyda, H.J.|
|Publisher||Erasmus MC: University Medical Center Rotterdam|
Drop, S.L.S.. (1983, October 12). Isolation of a somatomedin binding protein from human preterm amniotic fluid : development of a radioimmunoassay . Erasmus MC: University Medical Center Rotterdam. Retrieved from http://hdl.handle.net/1765/37582