Early trauma and familial risk in the development of the extended psychosis phenotype in adolescence
Objective: Both genetic and environmental factors are thought to play a role in the development of psychotic outcomes; however, their respective contributions over time, including possible developmental interactions, remain largely unknown. Method: The contribution of parental general and psychotic psychopathology as proxies of genetic risk to the development of subthreshold psychosis and its hypothesized interaction with childhood trauma were studied in a general population sample of 2230 adolescents, followed from age 10-16years. Outcome measures were: i) level of psychotic experiences at age 16years and ii) persistence of such experiences over the total follow-up period. Results: General parental psychopathology was associated with CAPE score (OR=1.08; P<0.043 for highest quintile) and suggestively predicted psychosis persistence (OR, 1.16; P<0.072). Psychotic parental psychopathology was suggestively associated with CAPE score (OR, 2.25; P<0.063 for highest quintile), predicted membership of the Persistent group (OR, 3.72; P<0.039) and suggestively predicted membership of the Decreasing group (OR 2.04; P<0.051). Childhood trauma was associated with CAPE score and with all developmental trajectories of subclinical psychosis. No evidence was found for an interaction between trauma and parental psychopathology. Conclusion: The development and persistence of subthreshold psychotic symptoms may be conditional on non-interacting proxy genetic and environmental influences.
|Keywords||Adolescence, Development, Parental psychopathology, Psychosis, Trauma|
|Persistent URL||dx.doi.org/10.1111/j.1600-0447.2012.01857.x, hdl.handle.net/1765/37630|
Wigman, J.T.W., van Winkel, R., Ormel, J., Verhulst, F.C., van Os, J., & Vollebergh, W.A.M.. (2012). Early trauma and familial risk in the development of the extended psychosis phenotype in adolescence. Acta Psychiatrica Scandinavica, 126(4), 266–273. doi:10.1111/j.1600-0447.2012.01857.x