Two Sides of the Same Coin : Unravelling the role of transcription factors and miRNAs in activated monocytes, macrophages and microglia
This thesis focusses on understanding the role of three transcriptions factors, namely ATF3, EGR3 and PU.1, and also microRNA-146a, involved in the activation of monocytes, macrophages and microglia in pathological conditions, which are thought to be driven – at least in part – by special inflammatory reactions. The diseases in question are severe psychiatric diseases, such as bipolar disorder, major depression, schizophrenia and postpartum psychosis and X-linked juvenile retinoschisis. In the introduction the immune cells, the diseases and the transcription factors + pathways will be introduced subsequently.
|Keywords||T cells, immunology, inflammatory diseaseas, miRNAs|
|Promotor||Drexhage, H.A. (Hemmo) , Langmann, T. (Thomas)|
|Publisher||Erasmus University Rotterdam|
|Sponsor||The studies were financially supported by the European Commission EU-FP7- HEALTH-F2-2008-222963 ‘MOODINFLAME’, ZonMW-TOP-91208018, The Pro Retina Foundation Germany, the German Research Foundation (DFG) and the J.E. Jurriaanse Stichting|
Weigelt, K.. (2012, November 7). Two Sides of the Same Coin : Unravelling the role of transcription factors and miRNAs in activated monocytes, macrophages and microglia. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/37641