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C.W. Ang (Wim), A.P. Tio-Gillen (Anne), J. Groen (Jan), P. Herbrink (Paul), B.C. Jacobs (Bart), A.D.M.E. Osterhaus (Albert), P.A. van Doorn (Pieter), F.G.A. van der Meché (Frans) and R. van Koningsveld (Rinske)

2002-09-01

Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in the Guillain-Barré syndrome.

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Anti-galactocerebroside (GalC) antibodies are reported to be present in GBS patients with preceding Mycoplasma pneumoniae (MP) infection. We investigated the presence of anti-GalC reactivity in serum of a large group of GBS patients using ELISA and compared this with healthy controls and individuals with an uncomplicated MP infection. Anti-GalC antibody reactivity was present in 12% of the GBS patients. Furthermore, anti-GalC antibodies were associated with MP infections, a relatively mild form of the disease and demyelinating features. Anti-GalC antibodies cross-reacted with MP antigen. In conclusion, anti-GalC antibodies in GBS patients may be induced by molecular mimicry with MP.

Additional Metadata
Keywords Molecular mimicry, Mycoplasma pneumoniae, Neuropathy
Persistent URL doi.org/10.1016/S0165-5728(02)00209-6, hdl.handle.net/1765/3894
Organisation Erasmus MC: University Medical Center Rotterdam
Citation
Ang, W., Tio-Gillen, A., Groen, J., Herbrink, P., Jacobs, B., Osterhaus, A., … van Koningsveld, R. (2002). Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in the Guillain-Barré syndrome. doi:10.1016/S0165-5728(02)00209-6
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