Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in the Guillain-Barré syndrome.
Anti-galactocerebroside (GalC) antibodies are reported to be present in GBS patients with preceding Mycoplasma pneumoniae (MP) infection. We investigated the presence of anti-GalC reactivity in serum of a large group of GBS patients using ELISA and compared this with healthy controls and individuals with an uncomplicated MP infection. Anti-GalC antibody reactivity was present in 12% of the GBS patients. Furthermore, anti-GalC antibodies were associated with MP infections, a relatively mild form of the disease and demyelinating features. Anti-GalC antibodies cross-reacted with MP antigen. In conclusion, anti-GalC antibodies in GBS patients may be induced by molecular mimicry with MP.
|Keywords||Molecular mimicry, Mycoplasma pneumoniae, Neuropathy|
|Persistent URL||dx.doi.org/10.1016/S0165-5728(02)00209-6, hdl.handle.net/1765/3894|
Ang, C.W., Tio-Gillen, A.P., Groen, J., Herbrink, P., Jacobs, B.C., Osterhaus, A.D.M.E., … van Koningsveld, R.. (2002). Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in the Guillain-Barré syndrome.. doi:10.1016/S0165-5728(02)00209-6