Aetiology: Koch's postulates fulfilled for SARS virus
Severe acute respiratory syndrome (SARS) has recently emerged as a new human disease, resulting globally in 435 deaths from 6,234 probable cases (as of 3 May 2003). Here we provide proof from experimental infection of cynomolgus macaques (Macaca fascicularis) that the newly discovered SARS-associated coronavirus (SCV) is the aetiological agent of this disease. Our understanding of the aetiology of SARS will expedite the development of diagnostic tests, antiviral therapies and vaccines, and may allow a more concise case definition for this emerging disease.
|Keywords||*Disease Models, Animal, Animals, Cercopithecus aethiops, Exanthema/complications, Feces/virology, Lung/pathology/virology, Macaca fascicularis/immunology/*virology, Nasal Cavity/virology, Pharynx/virology, SARS Virus/immunology/isolation & purification/*pathogenicity/*physiology, Severe Acute Respiratory Syndrome/complications/immunology/*pathology/*virology, Sleep Stages, Time Factors, Vero Cells|
|Persistent URL||dx.doi.org/10.1038/423240a, hdl.handle.net/1765/3911|
Fouchier, R.A.M., Kuiken, T., Peiris, M., Lim, W., Stohr, K., Osterhaus, A.D.M.E., … Schutten, M.. (2003). Aetiology: Koch's postulates fulfilled for SARS virus. Nature: international weekly journal of science, 423(6937), 240–240. doi:10.1038/423240a