1992-10-01
Subcutaneous pancreas transplantation : an experimental study in rats and dogs
Publication
Publication
Subcutane pancreas transplantatie : een experimenteel onderzoek in ratten en honden
The aim of this study was to investigate whether subcutaneous pancreas transplantation is a feasible technique which results in long-term insulin-independence, which can be used in early pancreas transplantation, before late diabetic complications will develop. In this surgical model also the third condition for early pancreas transplantation was tested: immunosuppressive protocols with non- or low-toxicity. Especially biological procedures (blood transfusions and anti-class-U donor pretreatment) were used in combination with low-dose immunosuppressive drugs. The studies were performed in an experimental rat model and a preclinical dog model The next specific questions were studied: can long-term pancreas-graft function be achieved if placed in a subcutaneous position? has this position immunological consequences? can effective immunosuppressive protocols be developed with no or minimal sideeffects, resulting in long-term graft function?
Additional Metadata | |
---|---|
, , , , | |
J. Jeekel (Hans) | |
Erasmus University Rotterdam | |
hdl.handle.net/1765/40737 | |
Organisation | Erasmus MC: University Medical Center Rotterdam |
Spillenaar Bilgen, E. J. (1992, October). Subcutaneous pancreas transplantation : an experimental study in rats and dogs. Retrieved from http://hdl.handle.net/1765/40737 |
Additional Files | |
---|---|
0861_SPILLENAAR BILGEN, Ernst Johan.jpg Cover Image , 78kb | |
stellingen Spillenaar Bilgen.pdf , 28kb |