2012-02-22
Molecular Profiling of Non-small Cell Lung Carcinomas : A Genome-wide DNA Methylation Analysis
Publication
Publication
Moleculaire profielen van het niet-kleincellig longcarcinoom Een genoom-brede analyse van DNA methylering
DNA methylation is a signaling marker used by the cell to control gene expression, to keep genes silenced or active. It is an important part of what is called epigenetic controlling mechanisms (epi- Greek: επί- over, above, outer). We are just beginning to understand the intricate processes involving this type of epigenetic regulation and its role in normal development and carcinogenesis. In most types of cancers, a combination of environmental, genetic and epigenetic factors is implicated in initiating and maintaining the disease. Non-small cell lung carcinoma is a complex malignancy, posing challenges to accurate diagnosis and prognosis, which are essential for the correct choice of treatment. Despite recent advances in molecular biology and oncology, diagnosis is still largely based on classical histological classification.
| Additional Metadata | |
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| , , | |
| The research described in this thesis was financially supported by the Netherlands Genomics Initiative (NGI) through the Cancer Genomics Centre (CGC) | |
| J.N.J. Philipsen (Sjaak) | |
| Erasmus University Rotterdam | |
| hdl.handle.net/1765/41030 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Hughes Carvalho, R. (2012, February 22). Molecular Profiling of Non-small Cell Lung Carcinomas : A Genome-wide DNA Methylation Analysis. Retrieved from http://hdl.handle.net/1765/41030 |
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| Additional Files | |
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| 3478_Hughes Carvalho, Rejane.jpg Cover Image , 42kb | |
| stellingen Hughes Carvalho.pdf , 26kb | |
