Maintenance of increased coronary blood flow in excess of demand by nisoldipine administered as an intravenous infusion
Systemic and hemodynamic effects of nisoldipine, administered as a 4.5-micrograms/kg intravenous bolus over 3 minutes followed immediately by an infusion of 0.2 microgram/kg/min over 30 minutes, were studied in 13 patients undergoing diagnostic catheterization for suspected coronary artery disease or follow-up catheterization after coronary angioplasty. Responses to the drug tended to be exaggerated in the first 8 minutes of the infusion, but thereafter produced a steady state, with heart rate increased by 14 +/- 3% at 16 minutes and by 15 +/- 3% at 24 minutes (p less than 0.05), mean aortic pressure decreased 12 +/- 2% and 13 +/- 3% at the same times (p less than 0.05) and coronary venous blood flow increased by 31 +/- 5% and 34 +/- 6% (p less than 0.05). Myocardial oxygen consumption and the heart rate-systolic aortic pressure product were unchanged and cardiac output and stroke volume were significantly increased. Study during matched coronary sinus pacing produced similar trends. Nisoldipine is a potent coronary and peripheral vasodilator that maintains an increase in myocardial oxygen supply in excess of demand when given as an intravenous infusion.
|Keywords||21829-25-4 (Nifedipine), 63675-72-9 (Nisoldipine), Coronary Circulation/*drug effects, Female, Hemodynamic Processes/drug effects, Human, Infusions, Intravenous, Male, Middle Aged, Myocardium/metabolism, Nifedipine/administration & dosage/*analogs & derivatives/pharmacology, Nisoldipine, Oxygen Consumption/drug effects|
Soward, A.L., de Feyter, P.J., Hugenholtz, P.G., & Serruys, P.W.J.C.. (1986). Maintenance of increased coronary blood flow in excess of demand by nisoldipine administered as an intravenous infusion. The American Journal of Cardiology, 58, 1204–1208. Retrieved from http://hdl.handle.net/1765/4217