Sonotherapy; antirestenotic therapeutic ultrasound in coronary arteries: the first clinical experience.
We studied the safety and feasibility of intracoronary sonotherapy (IST) and its effect on the coronary vessel at 6 months. Thirty-seven patients with stable or unstable angina were included (40 lesions). The indication was de novo lesion (n = 26), restenosis (n = 2), in-stent restenosis (n = 11), and a total occlusion of a venous bypass graft. After successful angioplasty, IST was performed using a 5 Fr catheter with three serial ultrasound transducers operating at 1 MHz. IST was successfully performed in 36 lesions (success rate, 90%). IST exposure time per lesion was 718 ± 127 sec. During hospital stay, one patient died due to a bleeding complication. At 6-month follow-up, one patient experienced acute myocardial infarction, eight patients underwent repeat PTCA. No patient underwent CABG. Late lumen loss was 1.05 ± 0.70 mm with a restenosis rate of 25%. IVUS analysis revealed a neointima burden of 25% ± 11%. IST can be applied safely and with high acute procedural success. Sonotherapy-related major adverse events were not observed. Late lumen loss and neointimal growth were similar to conventional PTCA approaches. These results justify the initiation of randomized clinical efficacy studies.
|Keywords||cardiovascular disease, coronary diseases, intracoronary sonotherapy|
|Persistent URL||dx.doi.org/10.1002/ccd.10617, hdl.handle.net/1765/4712|
Regar, E.S., Thury, A., van der Giessen, W.J., Sianos, G., Vos, J.R., Smits, P.C., … de Feyter, P.J.. (2003). Sonotherapy; antirestenotic therapeutic ultrasound in coronary arteries: the first clinical experience.. Catheterization and Cardiovascular Interventions, 60(1), 9–17. doi:10.1002/ccd.10617