Three-dimensional intravascular ultrasonic volumetric quantification of stent recoil and neointimal formation of two new generation tubular stents
Currently, several different designs of coronary stents are available. However, only a few of the new generation stents have been investigated in large randomized trials. Mechanical behavior of first-generation stents (Palmaz-Schatz, Gianturco-Roubin) may not be applied to the new designs. We investigated the chronic mechanical behavior (recoil) of 2 stents recently approved by the Food and Drug Administration (MULTILINK and NIR). Forty-eight patients with single-stent implantation (23 MULTILINK and 25 NIR) were assessed by means of volumetric 3-dimensional intravascular ultrasound analysis after the procedure and at 6-month follow-up. In addition, volumetric assessment of neointimal formation was performed. No significant chronic stent recoil was detected in both groups (Δ MULTILINK stent volume: +5.6 ± 41 mm3 [p = NS] and Δ NIR stent volume + 2.1 ± 26 mm3 [p = NS]). A similar degree of neointimal formation at 6 months was observed between the 2 stents (MULTILINK 46 ± 31.9 mm3 vs NIR 39.9 ± 27.6 mm3, p = NS). In conclusion, these 2 second-generation tubular stents did not show chronic recoil and appeared to promote similar proliferative response after implantation in human coronary arteries.
|Keywords||coronary stents, stenosis|
|Persistent URL||dx.doi.org/10.1016/S0002-9149(99)00655-4, hdl.handle.net/1765/4905|
Costa, M.A., Sabaté, M., Kay, I.P., Kozuma, K., Serrano, P., de Valk, V., … de Feyter, P.J.. (2000). Three-dimensional intravascular ultrasonic volumetric quantification of stent recoil and neointimal formation of two new generation tubular stents. The American Journal of Cardiology, 85(2), 135–139. doi:10.1016/S0002-9149(99)00655-4