1990-03-08
Characterization of 5-hydroxytryptamine receptors in the cardiovascular system
Publication
Publication
Karakterisering van 5-hydroxytryptamine receptoren in het cardiovasculaire stelsel.
Until recently, mainly rats, guinea pigs, rabbits, cats and dogs were used to study the cardiovascular effects of 5-HT. From these studies it was clear that for some effects of 5-HT (e.g. 5-HT-induced tachycardia) there exists a large heterogeneity with respect to receptor subtype(s) and mechanism(s) (see Saxena, 1986). Therefore, the first part of the thesis deals with the mechanism and receptor type involved in the 5-HT-induced heart rate changes in the cat and the pig. In the second part of the thesis the effect of 5-HT and, other agonists at the 5-HT receptors on total carotid blood flow and its distribution are described. 5-HTz receptors have been shown to play a minor role in carotid blood flow changes (Verdouw et al., 1984). Therefore, the role of 5-HTt-like and 5-HT3 receptors has been determined
| Additional Metadata | |
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| , , , | |
| Erasmus University Rotterdam | |
| P.R. Saxena (Pramod Ranjan) | |
| hdl.handle.net/1765/50881 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Bom, A. (1990, March 8). Characterization of 5-hydroxytryptamine receptors in the cardiovascular system. Retrieved from http://hdl.handle.net/1765/50881 |
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