1989-01-11
Prediction and prevention of pregnancy-induced hypertensive disorders : a clinical and pathophysiologic study
Publication
Publication
Predictie en preventie van zwangerschapshypertensie: Een klinisch en pathofysiologisch onderzoek
pregnancyinduced hypertensive disease depends on a functional imbalance between two eicosanoid substances with opposing physiologic effects, it may be attempted to correct the putative imbalance by means of pharmacologic manipulation. The demonstration that such a pharmacologic intervention would result in preventing, halting or retarding the clinical signs of the disease (secondary prevention) would strongly support the hypothesis; on the other hand, the absence of a preventive effect of such an approach would cast significant doubt on the validity of the hypothesis. The description of the design, the execution and the results of such a clinical pathophysiologic study, using low-dose Aspirin, forms the core of this thesis. During the preparation of that study the need arose for a reliable method to define a population of pregnant women at risk. A survey of the pertinent literature revealed that a multitude of predictive tests for pregnancy-induced hypertensive disease has been proposed, but that their validity is ill-defined or controversial. On the basis of a critical search of the available literature we selected the two most promising predictive tests and determined their validity in an additional clinical study.
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Erasmus University Rotterdam | |
H.C.S. Wallenburg (Henk) | |
hdl.handle.net/1765/50999 | |
Organisation | Erasmus MC: University Medical Center Rotterdam |
Dekker, G. A. (1989, January 11). Prediction and prevention of pregnancy-induced hypertensive disorders : a clinical and pathophysiologic study. Retrieved from http://hdl.handle.net/1765/50999 |