Pathogenetic aspects of benign monoclonal gammapathy : studies in an experimental model

When after a period of observation it is concluded that an individual suffers from BMG, several matters of practical urgency have to be considered: For instance, what is the relationship between BMG and malignant MG? Does BMG represent a premyeloma stage? Is there any relationship between BMG and other nonmalignant MG? In fact, very few data concerning the etiology, pathogenesis and significance of BMG are available. Because of this lack of data, experimental studies in an animal model have been started. The experiments described in this thesis form part of these studies and are aimed at increasing insight into the pathogenesis of BMG. Special attention was paid to the effects of aging, the T-immune system, antigenic stimulation and genetic influences in the development of BMG. Before going further into this matter, the major features of BMG in humans will be presented in the next paragraph