2014-07-02
Clinical Relevance of Genetic Alterations in Acute Lymphoblastic Leukemia in Children with Down syndrome
Publication
Publication
Klinische relevantie van genetische afwijkingen in Acute Lymfatische Leukemie bij kinderen met het syndroom van Down
Abstract
Hematopoiesis encompasses the process by which mature peripheral blood cells are generated by differentiation of hematopoietic stem cells (HSC) in the bone marrow (BM). The daughter cells of HSC’s, progenitor cells, can each commit to the myeloid or lymphoid differentiation pathways that lead to the production of one or more specific types of mature blood cells. These cells are then released in the peripheral blood. The myeloid lineage generates platelets, erythrocytes, granulocytes (basophils, neutrophils and eosinophils) and monocytes, whereas the lymphoid lineage differentiates into T and B-lymphocytes.
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| , , , , , , | |
| R. Pieters (Rob) | |
| Erasmus University Rotterdam | |
| The work described in this thesis was performed at the Department of Paediatric Oncology/ Haematology of the Erasmus Medical Centrum, Sophia Children’s Hospital, Rotterdam, the Netherlands. This work was funded by KinderenKankervrij (KIKA) and the Paediatric Oncology Foundation Rotterdam (KOCR) Publication of this thesis was financially supported by: Erasmus Universtity Rotterdam, Stichting Kinderoncologisch Centrum Rotterdam, MRC Holland and AMGEN BV. | |
| hdl.handle.net/1765/51606 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Buitenkamp, T. (2014, July 2). Clinical Relevance of Genetic Alterations in Acute Lymphoblastic Leukemia in Children with Down syndrome. Retrieved from http://hdl.handle.net/1765/51606 |
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