2013-09-01
Establishing in vitro to clinical correlations in the evaluation of cardiovascular safety pharmacology
Publication
Publication
Drug Discovery Today: Technologies , Volume 10 - Issue 3
Preclinical studies are vital in establishing the efficacy and safety of a new chemical entity (NCE) in humans. To deliver meaningful information, experiments have to be well defined and provide outcome that is relevant and translatable to humans. This review briefly surveys the various preclinical experiments that are frequently conducted to assess drug effects on cardiac conductivity in early drug development. We examine the different approaches used to establish correlations between non-clinical and clinical settings and discuss their value in the evaluation of cardiovascular risk.
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doi.org/10.1016/j.ddtec.2012.07.001, hdl.handle.net/1765/54412 | |
Drug Discovery Today: Technologies | |
Organisation | Department of Medical Informatics |
Chain, A. S. Y., Sturkenboom, M., Danhof, M., & Pasqua, O. E. D. (2013). Establishing in vitro to clinical correlations in the evaluation of cardiovascular safety pharmacology. Drug Discovery Today: Technologies (Vol. 10). doi:10.1016/j.ddtec.2012.07.001 |