1995
p53 modulation of TFIIH-associated nucleotide excision repair activity
Publication
Publication
Nature Genetics , Volume 10 - Issue 2 p. 188- 195
p53 has pleiotropic functions including control of genomic plasticity and integrity. Here we report that p53 can bind to several transcription factor IIH−associated factors, including transcription−repair factors, XPD (Rad3) and XPB, as well as CSB involved in strand−specific DNA repair, via its C−terminal domain. We also found that wild−type, but not Arg273His mutant p53 inhibits XPD (Rad3) and XPB DNA helicase activities. Moreover, repair of UV−induced dimers is slower in Li−Fraumeni syndrome cells (heterozygote p53 mutant) than in normal human cells. Our findings indicate that p53 may play a direct role in modulating nucleotide excision repair pathways.
| Additional Metadata | |
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| doi.org/10.1038/ng0695-188, hdl.handle.net/1765/54884 | |
| Nature Genetics | |
| Organisation | Department of Molecular Genetics |
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Wang, X. W., Yeh, H., Schaeffer, L., Roy, R., Moncollin, V., Egly, J.-M., … Harris, C. C. (1995). p53 modulation of TFIIH-associated nucleotide excision repair activity. Nature Genetics, 10(2), 188–195. doi:10.1038/ng0695-188 |
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