2002-04-01
Ontogeny and genetics of the hemato/lymphopoietic system
Publication
Publication
Current Opinion in Immunology , Volume 14 - Issue 2 p. 186- 191
During embryogenesis there is a sequential, temporal appearance of increasingly more-complex hematopoietic cells beginning with unipotential progenitors, proceeding to multipotential (myeloid, erythroid and lymphoid) progenitors and culminating with adult-repopulating hematopoietic stem cells. Current research has established an important role for the aorta-gonads-mesonephros region of the mouse embryo in the generation of multipotential progenitors and hematopoietic stem cells. Comparisons of normal and hematopoietic-cell-mutant mouse embryos have revealed several genes pivotal in hematopoietic stem cell generation/function. Other genes have been implicated in the critical generation of lymphoid lineage potential. Thus, an understanding of the cellular and molecular interactions within the midgestation aorta-gonads-mesonephros region offers insight into the mechanisms of hematopoietic lineage specification during ontogeny and perhaps will lead to a more complete knowledge of the adult hematopoietic system.
Additional Metadata | |
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doi.org/10.1016/S0952-7915(02)00320-5, hdl.handle.net/1765/55457 | |
Current Opinion in Immunology | |
Organisation | Biophysical Genomics, Department Cell Biology & Genetics |
Ling, K.-W., & Dzierzak, E. (2002). Ontogeny and genetics of the hemato/lymphopoietic system. Current Opinion in Immunology (Vol. 14, pp. 186–191). doi:10.1016/S0952-7915(02)00320-5 |