2013-10-01
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
Publication
Publication
Nature Genetics , Volume 45 - Issue 10 p. 1150- 1159
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-Analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.
| Additional Metadata | |
|---|---|
| doi.org/10.1038/ng.2742, hdl.handle.net/1765/55967 | |
| Nature Genetics | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
|
Ripke, S., O'Dushlaine, C., Chambert, K., Moran, J. L., Kähler, J., Akterin, S., … Sullivan, P. (2013). Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature Genetics, 45(10), 1150–1159. doi:10.1038/ng.2742 |
|