2012-08-13
The quasi-stable lipid shelled microbubble in response to consecutive ultrasound pulses
Publication
Publication
Applied Physics Letters , Volume 101 - Issue 7
Controlled microbubble stability upon exposure to consecutive ultrasound exposures is important for increased sensitivity in contrast enhanced ultrasound diagnostics and manipulation for localised drug release. An ultra high-speed camera operating at 13 × 10 6 frames per second is used to show that a physical instability in the encapsulating lipid shell can be promoted by ultrasound, causing loss of shell material that depends on the characteristics of the microbubble motion. This leads to well characterized disruption, and microbubbles follow an irreversible trajectory through the resonance peak, causing the evolution of specific microbubble spectral signatures.
| Additional Metadata | |
|---|---|
| doi.org/10.1063/1.4746258, hdl.handle.net/1765/56068 | |
| Applied Physics Letters | |
| Organisation | Department of Cardiology |
|
Thomas, D., Butler, M., Anderson, T., Emmer, M., Vos, R., van der Borden, S. G., … Sboros, V. (2012). The quasi-stable lipid shelled microbubble in response to consecutive ultrasound pulses. Applied Physics Letters, 101(7). doi:10.1063/1.4746258 |
|