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A.H. Brandenburg (Afke), L. de Waal (Leon), H.H. Timmerman (Helga), P. Hoogerhout (Peter), R.L. de Swart (Rik) and A.D.M.E. Osterhaus (Albert)

2000

HLA class I-restricted cytotoxic T-cell epitopes of the respiratory syncytial virus fusion protein

Publication

Publication

Journal of Virology , Volume 74 - Issue 21 p. 10240- 10244

Virus-specific cytotoxic T lymphocytes (CTL) play a major role in the clearance of respiratory syncytial virus (RSV) infection. We have generated cytotoxic T-cell clones (TCC) from two infants who had just recovered from severe RSV infection. These TCC were functionally characterized and used to identify HLA class I (B57 and C12)-restricted CTL epitopes of RSV.

Additional Metadata
Keywords Epitope Mapping, Epitopes, T-Lymphocyte/*immunology, Histocompatibility Antigens Class I/*immunology/metabolism, Humans, Infant, Infant, Newborn, Research Support, Non-U.S. Gov't, Respiratory Syncytial Virus Infections/virology, Respiratory Syncytial Viruses/*immunology, T-Lymphocytes, Cytotoxic/*immunology, Viral Fusion Proteins/*immunology, Viral Proteins/*immunology
Persistent URL doi.org/10.1128/JVI.74.21.10240-10244.2000, hdl.handle.net/1765/57008
Journal Journal of Virology
Organisation Department of Virology
Citation
Brandenburg, A., de Waal, L., Timmerman, H., Hoogerhout, P., de Swart, R., & Osterhaus, A. (2000). HLA class I-restricted cytotoxic T-cell epitopes of the respiratory syncytial virus fusion protein. Journal of Virology, 74(21), 10240–10244. doi:10.1128/JVI.74.21.10240-10244.2000
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