1997-10-01
Investigation of the association of the CRTM and CRTL1 genes with radiographically evident osteoarthritis in subjects from the Rotterdam study
Publication
Publication
CRTM and CTRLI genes and radiographic OA
Arthritis & Rheumatology , Volume 40 - Issue 10 p. 1760- 1765
Objective: To investigate whether radiographically evident osteoarthritis (ROA) in 55-65-year-old men and women is associated with specific alleles or genotypes of the cartilage matrix protein (CRTM) and cartilage link protein (CRTLl) genes.
Methods: Cases were selected from a populationbased study on the presence of ROA of the knee or hip. Further radiographic analysis included scoring for spine and hand ROA. Controls, selected from the same population, were free of ROA in all joints.
Results: The CRTM locus was significantly associated with hip ROA in men (odds ratio 0.50, 95% confidence interval 0.26-0.95). A significant association between ROA and the CRTLl gene was not observed.
Conclusion: These results suggest that the CRTM locus may play a role in the sex- and joint site-specific pattern of ROA development.
| Additional Metadata | |
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| doi.org/10.1002/art.1780401006, hdl.handle.net/1765/57423 | |
| Arthritis & Rheumatology | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Meulenbelt, I., Bijkerk, C., de Wildt, S. C. M., Miedema, H., Valkenburg, H., Breedveld, F., … van Duijn, C. (1997). Investigation of the association of the CRTM and CRTL1 genes with radiographically evident osteoarthritis in subjects from the Rotterdam study. Arthritis & Rheumatology, 40(10), 1760–1765. doi:10.1002/art.1780401006 |
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