Occupational exposures to solvents and lead as risk factors for Alzheimer's disease: A collaborative re-analysis of case-control studies
A meta-analysis, involving the secondary analysis of original data from 11 case-control studies of Alzheimer's disease, is presented for occupational exposures to solvents and lead. Three studies had data on occupational exposure to solvents. Among cases, 21.3% were reported to have been exposed; among controls, this figure was comparable (20.9%). This yielded a pooled matched relative risk of 0.76 (95% CI: 0.47-1.23). Four studies had data on exposure to lead. Exposure frequencies were 6.1% in cases and 8.3% in controls. This resulted in a pooled matched relative risk of 0.71 (95% CI: 0.36-1.41). The meta-analysis was particularly useful in validating negative results from individual studies and in increasing the statistical power for the analysis of lead exposure, where stratum-specific cell sizes were frequently smaller than five in individual studies. However, since exposure in the various studies was ascertained in a rather broad manner, prospective studies are recommended which focus on high-risk occupational populations and which determine the incidence of Alzheimer's disease in these and comparable unexposed populations.
|Keywords||0 (Solvents), Alzheimer Disease/chemically induced/epidemiology, Case-Control Studies, Human, Lead Poisoning/complications, Meta-Analysis, Occupational Diseases/chemically induced, Risk Factors, Solvents/poisoning, United States/epidemiology, dementia|
|Note||Supplement 2, pp. S58-S61|
Graves, A.B., van Duijn, C.M., Chandra, V., Fratiglioni, L., Heyman, A., Jorm, A.F., … Hofman, A.. (1991). Occupational exposures to solvents and lead as risk factors for Alzheimer's disease: A collaborative re-analysis of case-control studies. International Journal of Epidemiology, 20, 58–61. Retrieved from http://hdl.handle.net/1765/5795