2004-10-01
Routine sirolimus eluting stent implantation for unselected in-stent restenosis: Insights from the Rapamycin Eluting Stent Evaluated at Rotterdam Cardiology Hospital (RESEARCH) registry
Publication
Publication
Heart , Volume 90 - Issue 10 p. 1183- 1188
Objective: To assess the effectiveness of routine sirolimus eluting stent (SES) implantation for unselected patients with in-stent restenosis and to provide preliminary information about the angiographic outcome for lesion subgroups and for different in-stent restenosis patterns. Design: Prospective, single centre registry. Setting: Tertiary referral centre. Patients: 44 consecutive patients (53 lesions) without previous brachytherapy who were treated with SES for in-stent restenosis were evaluated. Routine angiographic follow up was obtained at six months and the incidence of major adverse cardiovascular events was evaluated. Results: At baseline, 42% of the lesions were focal, 21% diffuse, 26% proliferative, and 11% total occlusions. Small vessel size (reference diameter ≤ 2.5 mm) was present in 49%, long lesions (> 20 mm) in 30%, treatment of bypass grafts in 13%, and bifurcation stenting in 18%. At follow up, post-SES restenosis was observed in 14.6%. No restenosis was observed in focal lesions. For more complex lesions, restenosis rates ranged from 20-25%. At the one year follow up, the incidence of death was 0, myocardial infarction 4.7% (n = 2), and target lesion revascularisation 16.3% (n = 7). The target lesion was revascularised because of restenosis in 11.6% (n = 5). Conclusions: Routine SES implantation is highly effective for focal in-stent restenosis and appears to be a promising strategy for more complex patterns of restenosis.
Additional Metadata | |
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doi.org/10.1136/hrt.2003.025536, hdl.handle.net/1765/58438 | |
Heart | |
Organisation | Department of Cardiology |
Saia, F., Lemos Neto, P., Arampatzis, C., Hoye, A., Degerlekin, M., Tanabe, K., … Serruys, P. (2004). Routine sirolimus eluting stent implantation for unselected in-stent restenosis: Insights from the Rapamycin Eluting Stent Evaluated at Rotterdam Cardiology Hospital (RESEARCH) registry. Heart, 90(10), 1183–1188. doi:10.1136/hrt.2003.025536 |