Apolipoprotein E genotype does not affect the age of onset of dementia in families with define tau mutations

Houlden, Henry; Stevens, Martijn; de Knijff, Peter; van Duijn, Cornelia; Heutink, Peter; Perez-Tur, Jordi; Thomas, Valerie; Baker, Matthew; Morris, Huw; Rossor, Martin; Jannsen, John; Petersen, Ronald; Dodd, Peter; Dark, Frances; Boeve, Bradley; Dickson, Dennis; Davies, Peter; Pickering-Brown, Stuart; Mann, David; Adamson, Jennifer; Lynch, Tim; Payami, Haydeh; Poorkaj, Parvoneh; Bird, Thomas; Schellenberg, Gerard; Chadraverty, S.; Norton, Joanne; Morris, Huw; Goate, Alison; Hutton, Michael; Hardy, John; Rizzu, Patrizia; van Swieten, John

doi:10.1016/S0304-3940(98)00931-8

We have assessed whether apolipoprotein E (ApoE) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. In contrast to the situation in Alzheimer's disease (AD), we could find no evidence that the age of onset of disease was influenced by the ApoE genotype.

Additional Metadata
Keywords	0 (Apolipoproteins E), 0 (tau Proteins), Age of Onset, Aged, Apolipoproteins E/genetics, Chromosomes, Human, Pair 17/genetics, Dementia/genetics/psychology, Frontal lobe dementia, Genotype, Human, Middle Aged, Mutation, Missense/physiology, Parkinson Disease/genetics, Support, Non-U.S. Gov't, Support, U.S. Gov't, P.H.S., tau Proteins/*genetics
Persistent URL	doi.org/10.1016/S0304-3940(98)00931-8, hdl.handle.net/1765/5886
Journal	Neuroscience Letters
Organisation	Erasmus MC: University Medical Center Rotterdam
Citation APA Style AAA Style APA Style Cell Style Chicago Style Harvard Style IEEE Style MLA Style Nature Style Vancouver Style American-Institute-of-Physics Style Council-of-Science-Editors Style BibTex Format Endnote Format RIS Format CSL Format DOIs only Format	Houlden, H., Stevens, M., de Knijff, P., van Duijn, C., Heutink, P., Perez-Tur, J., … van Swieten, J. (1999). Apolipoprotein E genotype does not affect the age of onset of dementia in families with define tau mutations. Neuroscience Letters, 260(3), 193–195. doi:10.1016/S0304-3940(98)00931-8

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Apolipoprotein E genotype does not affect the age of onset of dementia in families with define tau mutations

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Apolipoprotein E genotype does not affect the age of onset of dementia in families with define tau mutations

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