2004
Chromosomal Translocation t(18;21)(q23;q22.1) Indicates Novel Susceptibility Loci for Frontotemporal Dementia with ALS
Publication
Publication
Annals of Neurology , Volume 55 - Issue 1 p. 134- 138
A chromosomal translocation t(18;21)(q23;q22) is reported in a patient with frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We exclude the physical involvement and silencing of the ALS-linked gene for copper/zinc superoxide dismutase (SOD1) on chromosome 21q22.1. The breakpoints are assigned to sequences flanked by the markers ATA1H06, D18S462, D21S1915, and D21S1898. These critical regions may contain susceptibility loci for FTD associated with ALS.
| Additional Metadata | |
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| doi.org/10.1002/ana.10822, hdl.handle.net/1765/59147 | |
| Annals of Neurology | |
| Organisation | Department of Clinical Genetics |
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Prudlo, J., Alber, B., Kalscheuer, V., Roemer, M., Martin, T., Dullinger, J., … Meyer, T. (2004). Chromosomal Translocation t(18;21)(q23;q22.1) Indicates Novel Susceptibility Loci for Frontotemporal Dementia with ALS. Annals of Neurology, 55(1), 134–138. doi:10.1002/ana.10822 |
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