2013-09-01
An integrated population pharmacokinetic meta-analysis of propofol in morbidly obese and nonobese adults, adolescents, and children
Publication
Publication
CPT: Pharmacometrics and Systems Pharmacology , Volume 2 - Issue 9
This study describes a population pharmacokinetic meta-analysis of propofol to characterize the influence of body size measures and age in morbidly obese and nonobese adults, adolescents, and children. Sixty morbidly obese and nonobese adult patients (55-167 kg; 21-79 years) and 34 morbidly obese and nonobese adolescents and children (37-184 kg; 9-20 years) were included. The results show that clearance increased with total body weight in an allometric function while age was found to influence clearance in a bilinear fashion with two distinct slopes, reflecting an initial increase and subsequent decrease as a result of aging.Using these two functions, the influence of both (over)weight and age on propofol clearance was well characterized, which may provide a basis for dosing across this diverse group of patients.
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| doi.org/10.1038/psp.2013.47, hdl.handle.net/1765/59187 | |
| CPT: Pharmacometrics and Systems Pharmacology | |
| Organisation | Department of Anesthesiology |
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Diepstraten, J., Chidambaran, V., Sadhasivam, S., Blussé van Oud-Alblas, H., Inge, K. K., van Ramshorst, B., … Knibbe, C. (2013). An integrated population pharmacokinetic meta-analysis of propofol in morbidly obese and nonobese adults, adolescents, and children. CPT: Pharmacometrics and Systems Pharmacology, 2(9). doi:10.1038/psp.2013.47 |
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