2007-04-01
Evaluation of LRRK2 G2019S penetrance: Relevance for genetic counseling in Parkinson disease
Publication
Publication
Neurology , Volume 68 - Issue 14 p. 1141- 1143
We report the results of a family-based study of LRRK2 G2019S penetrance in Parkinson disease. We studied 19 families identified through the analysis of unrelated consecutive patients. The cumulative incidence of the disease was 15% at 60 years, 21% at 70 years, and 32% at 80 years. This study provides accurate estimates of G2019S penetrance by minimizing the selection bias.
| Additional Metadata | |
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| doi.org/10.1212/01.wnl.0000254483.19854.ef, hdl.handle.net/1765/59578 | |
| Neurology | |
| Organisation | Department of Clinical Genetics |
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Goldwurm, S., Zini, A., Mariani, L., Tesei, S., Miceli, R., Sironi, F., … Pezzoli, G. (2007). Evaluation of LRRK2 G2019S penetrance: Relevance for genetic counseling in Parkinson disease. Neurology, 68(14), 1141–1143. doi:10.1212/01.wnl.0000254483.19854.ef |
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