1995-08-24
Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia
Publication
Publication
New England Journal of Medicine , Volume 333 - Issue 8 p. 487- 493
In severe congenital neutropenia the maturation of myeloid progenitor cells is arrested. The myelodysplastic syndrome and acute myeloid leukemia develop in some patients with severe congenital neutropenia. Abnormalities in the signal-transduction pathways for granulocyte colony-stimulating factor (G-CSF) may play a part in the progression to acute myeloid leukemia.
| Additional Metadata | |
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| doi.org/10.1056/NEJM199508243330804, hdl.handle.net/1765/60338 | |
| New England Journal of Medicine | |
| Organisation | Department of Hematology |
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Dong, F., Brynes, R. K., Tidow, N., Welte, K., Löwenberg, B., & Touw, I. (1995). Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia. New England Journal of Medicine, 333(8), 487–493. doi:10.1056/NEJM199508243330804 |
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